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Symbol
Name
ID

Tlr4
toll-like receptor 4
MGI:96824

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Neutrophilia

Leukocytosis

Recurrent pharyngitis

Allergic rhinitis

Conjunctivitis

Pericarditis

Lymphadenopathy

Mediastinal lymphadenopathy

Splenomegaly

Crohn's disease

Peritonitis

Subacute progressive viral hepatitis

Pancreatitis

Iridocyclitis

Epididymitis

Eczematoid dermatitis

Atopic dermatitis

Erysipelas

Erythema nodosum

Recurrent skin infections

Skin rash

Asthma

Meningitis

Disease(s) Associated with TLR4

asthma

atopic dermatitis

Behcet's disease

familial mediterranean fever

hepatocellular carcinoma

temporal arteritis

Mouse Phenotypes

immune system phenotype

decreased macrophage apoptosis

abnormal osteoclast differentiation

abnormal macrophage chemotaxis

impaired neutrophil chemotaxis

decreased B cell proliferation

increased spleen weight

decreased memory B cell number

decreased B cell number

abnormal phagocyte morphology

abnormal spleen weight

abnormal T-helper 2 physiology

abnormal macrophage physiology

decreased macrophage cytokine production

abnormal microglial cell physiology

decreased circulating interleukin-6 level

increased circulating interleukin-6 level

abnormal cytokine level

abnormal interleukin level

abnormal tumor necrosis factor level

enlarged mesenteric lymph nodes

abnormal level of surface class II molecules

abnormal cytokine secretion

decreased interferon-beta secretion

decreased interleukin-1 beta secretion

decreased interleukin-10 secretion

decreased interleukin-6 secretion

decreased tumor necrosis factor secretion

decreased susceptibility to induced arthritis

increased susceptibility to induced arthritis

abnormal inflammatory response

abnormal acute inflammation

decreased acute inflammation

decreased susceptibility to endotoxin shock

liver inflammation

lung inflammation

abnormal susceptibility to infection

decreased susceptibility to bacterial infection

increased susceptibility to bacterial infection

increased susceptibility to Poxviridae infection induced morbidity/mortality

decreased susceptibility to Orthomyxoviridae infection

Availability

Mouse Genotype

Tlr4^lps-2J/Tlr4^lps-2J

Tlr4^Lps-3Btlr/Tlr4^Lps-3Btlr

Tlr4^lps-4Btlr/Tlr4^lps-4Btlr

Tlr4^lps-5Btlr/Tlr4^lps-5Btlr

Tlr4^Lps-6Btlr/Tlr4^Lps-6Btlr

Tlr4^lps-7Btlr/Tlr4^lps-7Btlr

Tlr4^Lps-8Btlr/Tlr4^Lps-8Btlr

Tlr4^lps-Btlr/Tlr4^lps-Btlr

Tlr4^Lps-d/Tlr4^Lps-d

*

Tlr4^lps-del/Tlr4^lps-del

Tlr4^lps-hypo/Tlr4^lps-hypo

Tlr4^lps-n/Tlr4^lps-n

*

Tlr4^tm1.1Djh/Tlr4^tm1.1Djh

Tlr4^tm1Aki/Tlr4^tm1Aki

Tlr4^Lps-2Btlr/Tlr4⁺

Tlr4^Lps-3Btlr/Tlr4⁺

Tlr4^lps-4Btlr/Tlr4⁺

Tlr4^Lps-6Btlr/Tlr4⁺

Tlr4^lps-7Btlr/Tlr4⁺

Tlr4^Lps-8Btlr/Tlr4⁺

Tlr4^tm1Aki/Tlr4^lps-2J

Tlr4^Lps-2Btlr/?

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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